In the first game I played with my friends, we played the '42 setup. The Allied team decided upon this strategy: UK vs Italy then Germany, USSR vs Germany, USA vs Japan. Needless to say, it went horribly.
First, even with the USA going full tilt against Japan, it was unable to seriously bring it down. By the end of the game, the Imperial Navy was still strong, and the Japanese army had made major grounds in China and the Soviet east. Allied victory in the Pacific seemed far off, despite gains in Borneo, the Philippines, and long range aircraft (which really helped speed things up).
Second, while the British campaign against Italy initially went well, it became a protracted campaign that wasn’t really going anywhere. The intention for the British was to quickly destroy the Italian navy and then take Rome before it could adequately defend itself. The first part of the plan was a glowing success, but the second, not so much. Italy proved to be a tougher shell to crack, and Germany was becoming too powerful. Thus, the British decided to let Italy be and focus on D-Day landings.
Third, the German campaign in Russia went really well. They had advanced artillery and paratroopers, and really gave the Soviets a licking. The Russian military collapsed rather quickly, mostly due to over extending themselves when they should have probably been more defensively minded. It wasn’t long until Moscow was surrounded and under siege. Moscow fell two rounds before the Allies gave up.
The game could have probably kept on going, but it was getting late, and no one was interested in a protracted war of attrition.
Endgame incomes with NO’s (approximations)
USA- 65ish
UK- 35-40
USSR- 0
Japan- 33
Germany- 70-75
Italy- 9